All CPA marketers put their eggs in one basket. I’ve seen plenty of the greats go from zero to hero and vice versa several time in their careers. The smart ones learn to build their own business in the process and pimp their products to CPA newbies (where the real money is). So if your only focus is to make the most money you can I would advise you not to spend it all because that business model won’t last.
Never use AdSense on your affiliate marketing pages. You will potentially earn much more from a click on an affiliate link than on an advert. If you publish any clickable link on a page also containing a link to an affiliate pre sales or sales page, then you are diluting your potential income from that page. Why pass up the chance of a $47 sale to get a 20 cent click on an AdSense ad? That is not an exaggeration, yet some people do that!
The amount of money you can make can depend greatly of you budget. If you have a small budget and you don´t have a lot of money, then you have to start with free marketing methods like article writing, blogging, forum marketing and such. It takes a lot more effort ant time to have success with these methods. But they are very effective if you keep writing articles and participate in forums. You can make $100 a day within just a few months just with article marketing.